ABHIGNA N U
PhD | Bioinformatician | CSIR-JRF AIR 116 | Translational Computational Biology | Multi-omics & NGS | Structural Bioinformatics | ASO & Aptamer Design | Drug Discovery
Contact Me
Professional Summary
PhD-trained Bioinformatician with 4+ years of experience at the intersection of computational biology, structural bioinformatics, and precision therapeutics. Qualified CSIR-JRF (AIR 116) with research focused on targeting disease-associated microbial and human genes using antisense oligonucleotides (ASOs) through multi-omics analysis, molecular modeling, and wet-lab validation.
Published in international journals, contributed to patent filings, and developed computational tools including web servers. Proven ability to translate research into application-oriented outcomes for industry, CROs, startups, and research teams.
Core Expertise
NGS & Multi-Omics
RNA-seq, transcriptomics, proteomics analysis and integration for disease mechanism discovery
Structural Bioinformatics
Molecular docking, molecular dynamics simulations using Schrödinger Suite and GROMACS
Therapeutic Design
Antisense oligonucleotide (ASO) and aptamer design for precision therapeutics
Microbiome Genomics
Gut microbiome analysis and translational research for cardiovascular disease associations
Freelance Bioinformatics Consulting
2025 - Present
Remote
Services Offered
  • Structural bioinformatics, docking, and in silico validation for drug discovery
  • ASO and aptamer design strategy, feasibility analysis, and optimization
  • Multi-omics data integration and interpretation
  • Publication-ready outputs with reproducible workflows
  • Custom bioinformatics pipeline development
Delivering bioinformatics and computational biology support to research groups, startups, CROs, and early-stage teams worldwide. Specializing in translating complex biological data into actionable insights for therapeutic development.
Senior Research Fellow
JSS Academy of Higher Education & Research
Feb 2023 - Jan 2026
Pipeline Development
Led end-to-end bioinformatics pipelines for gut microbiome-cardiovascular disease association studies
ASO Design
Designed and optimized antisense oligonucleotides targeting microbial and human gene transcripts
Structural Analysis
Performed molecular docking and dynamics simulations using Schrödinger Suite and GROMACS
Data Integration
Analyzed NGS, transcriptomics, and proteomics datasets for translational insights
Research Contributions & Innovation
NCBI GenBank Submissions
Submitted and curated nucleotide sequences including 16S rRNA and functional gene sequences with validated accession records:
  • PQ277053.1 - cutC / TMA lyase sequence
  • PQ410724.1 - Functional gene annotation
  • PQ39941.1 - 16S rRNA sequence
  • PQ242626.1 - Microbial gene sequence
Software Development
Developed RNA2DNA, a web server for converting 3D structures of ssRNA to ssDNA (Software Copyright No. 18964/2023-CO/SW)
Impact
Built custom bioinformatics workflows, scripts, and advanced visualizations supporting reproducible research. Authored peer-reviewed publications and contributed to patent and software copyright filings.
SARS-CoV-2 Aptamer Biosensor Development
CSIR-CFTRI
Jan 2020 - Feb 2022
Developed aptamer-based biosensors for SARS-CoV-2 detection, resulting in published patent (Patent No. 202411017997). Integrated wet-lab validation with computational analysis, applying molecular docking and dynamics simulations to optimize aptamer-protein binding. Collaborated with interdisciplinary teams across molecular biology, bioinformatics, and analytics.
Educational Background
1
Doctor of Philosophy - PhD
JSS Academy of Higher Education & Research
Bioinformatics | April 2022 - January 2026
2
Master of Science
JSS Academy of Higher Education & Research
Bioinformatics | 2016 - 2018
3
Bachelor of Science
Yuvarajas College Mysore
Biochemistry, Microbiology, Biotechnology | 2013 - 2016
Certifications & Achievements
CSIR-UGC JRF
All India Rank 116
Life Sciences | 2019
KSET Qualified
Karnataka State Eligibility Test
Life Sciences | 2019
Patent Published
Patent No. 202411017997
SARS-CoV-2 Aptamer Biosensor
Software Copyright
No. 18964/2023-CO/SW
RNA2DNA Web Server
Let's Connect
Open to Opportunities
I am actively seeking industry, CRO, and startup roles, as well as freelance and consulting projects (remote/global). My expertise spans bioinformatics analysis, multi-omics interpretation, molecular modeling, and therapeutic target discovery.
Contact Information
Mobile: 08073727622
Location: Bengaluru, Karnataka, India
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